The worst of the worst are incarcerated in U.S.H.E.R.'s Rock City prison on Alcatraz Island. These are the 22 most dangerous men and women alive, criminals only one jail could hold.
- Brimstone: her touch is a fiery death, her breath the poisonous smoke of an erupting volcano
- Gale Force: a living creature of air, he can generate a wind to knock down a building or steal the breath from your lungs
- Permafrost: like the arctic she can kill you slowly or in minutes
- Sculpture: the man of granite
- Lunatic: a man with the strength and ferocity of a feral beast, he hunts by night and humans are his favorite prey.
- Throttle: as fast and deadly as a bullet, anything he can't fly around he can fly through.
- Aura: beautiful and deadly, this alien lives off the lifeforce of sentient creatures and Dr. Frazier has promised her more than she could ever consume in the bloated race of humanity.
- Grotesque: a gargoyle made flesh, this relentless killer claims to be a mystical creature. Regardless, his sadistic pleasure in the death of the living makes him a terror no one wants to confront.
- Dr. Walter Frazier: this time traveling genius from the future has concluded that only the most radical solution can save humanity from itself.